Design and evaluation of fast dissolving tablets of clonazepam
نویسندگان
چکیده
منابع مشابه
Design and Evaluation of Fast Dissolving Tablets of Clonazepam
In the present work, fast dissolving tablets of clonazepam were prepared by direct compression method with a view to enhance patient compliance. Three super-disintegrants, viz., crospovidone, croscarmellose sodium and sodium starch glycolate in different ratios with microcrystalline cellulose (Avicel PH-102) along with directly compressible mannitol (Pearlitol SD 200) to enhance mouth feel. The...
متن کاملFormulation Design and Optimization of Fast Dissolving Clonazepam Tablets
Fast dissolving tablets of clonazepam were prepared by direct compression method with a view to enhance patient compliance. A 3(2) full factorial design was applied to investigate the combined effect of two formulation variables: amount of crospovidone and microcrystalline cellulose. Crospovidone (2-8% w/w) was used as superdisintegrant and microcrystalline cellulose (20-40% w/w) was used as di...
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tablet formulation (t 16.4 min). Short-term stability studies on the formulation indicated that there are no significant changes in drug 50% content and in vitro dispersion time (p<0.05).
متن کاملFormulation Design and Optimization of Fast Dissolving Clonazepam Tablets by Sublimation Method
Fast dissolving tablets of clonazepam were prepared by sublimation method with a view to enhance patient compliance. A 3(2) full factorial design was applied to investigate the combined effect of two formulation variables: amount of croscarmellose sodium and camphor. Croscarmellose sodium (2-8% w/w) was used as superdisintegrant and camphor (20-40% w/w) was used as subliming agent, to increase ...
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Drug delivery system is an efficient tool for enhancing market, extending product life cycles and creating opportunities. Drug delivery system (DDS) makes a significant contribution to global pharmaceutical sales through market segmentation, and is moving rapidly[1]. Despite of tremendous innovations in drug delivery, the oral route remains the preferred route for administration of therapeutic ...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Sciences
سال: 2008
ISSN: 0250-474X
DOI: 10.4103/0250-474x.49125